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为探讨环境因素对飞行人员的影响，８０只Ｗｉｓｔａｒ大鼠随机分为：高温组、噪声组、两组条件相加的复合组和对照组。用特异性放射免疫法测定各组血浆心钠素（ＡＮＰ）、心脏扩张素（ＣＤＤ）、内源性洋地黄因子（ＥＤＬＳ）、血管紧张素Ⅱ（ＡⅡ）及内皮素（ＥＴ）含量。高温组血浆ＡＮＰ含量明显低于对照组（Ｐ＜０．０５）。高温组、噪声组血浆ＣＤＤ含量明显高于对照组（Ｐ＜０．０５）。高温组、噪声组及复合组血浆ＡⅡ明显高于对照组（Ｐ＜０．０５）。复合组血浆ＥＴ含量明显低于对照组（Ｐ＜０．０５）。各组ＥＤＬＳ含量无显著差异。提示：ＡＮＰ、ＣＤＤ、ＡⅡ含量变化与高温、噪声引起大鼠脱水、失盐及交感神经兴奋、肾素分泌增加有关，为机体的代偿反应。
In order to explore the impact of environmental factors on pilots, 80 Wistar rats were randomly divided into high temperature group, noise group, compound group and control group. The levels of plasma atrial natriuretic peptide (ANP), cardiac dilator (CDD), endogenous digitalis (EDLS), angiotensin Ⅱ (AⅡ) and endothelin (ET) were determined by radioimmunoassay. Plasma ANP levels in the high temperature group were significantly lower than those in the control group (P <0.05). In high temperature group, plasma CDD level in noise group was significantly higher than that in control group (P <0.05). The plasma AⅡ levels in high temperature group, noise group and compound group were significantly higher than those in control group (P <0.05). The content of plasma ET in the combined group was significantly lower than that in the control group (P <0.05). EDLS content in each group no significant difference. Tip: ANP, CDD, A Ⅱ content changes with high temperature and noise caused dehydration rats, loss of salt and sympathetic nerve stimulation, increased renin secretion, the body compensatory response.