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国内目前主要用于抗癫痫的药物有卡马西平、丙戊酸、苯妥英钠、苯巴比妥等,这些药物经临床使用,疗效已基本确定.但是,它们的药物动力学过程存在着明显的个体差异,而且药物本身治疗窗较窄,容易发生不良反应.因此,进行血药浓度监测,提倡个体化给药显得十分必要.我院从1987年起就已经开展了抗癫痫药物血药浓度监测工作,采用方法为高效波相色谱法和气相色谱法.经过多年的实践,测定方法日趋成熟,测定结果为临床开展个体化给药提供了很多有价值的参考.现将1994年后我院400例用液相色谱监测抗癫痫药物血药浓度结果以及部分病人临床随访调查作一分析.
The main drugs currently used for anti-epilepsy are carbamazepine, valproic acid, phenytoin sodium, phenobarbital, etc. These drugs have been clinically used clinically and their efficacy has been basically confirmed. However, their pharmacokinetic processes have obvious Individual differences, and the drug itself narrow therapeutic window, prone to adverse reactions.Therefore, blood concentration monitoring, to promote individualized administration is very necessary.Our hospital since 1987 has been carried out antiepileptic drug blood concentration monitoring Work, using methods for high performance wave and gas chromatography. After many years of practice, the determination method is maturing, the measurement results provide a lot of valuable clinical reference to individualized administration. Now after 1994 our hospital 400 Cases of liquid chromatography monitoring of antiepileptic drug plasma concentration results and some patients clinical follow-up survey for an analysis.