本文应用哌合西平(50mg,bid)治疗消化性溃疡23例与西咪替丁(1.0g/d)组26例进行对照研究。疗程均为6wk,由内窥镜检查评定疗效。结果表明,哌仑西平与西咪替丁2组溃疡愈合有效率分别为61％(14/23)与81％(21/26);2组止痛有效率分别为65％(15/23)与33％(6/18),均无统计学差异。因此,哌仑西平对消化性溃疡的疗效与西咪替丁相似。哌仑西平组的不良反应有口干、视力模糊等,似较西咪替丁组为多。 In this paper, pepeloxepin (50mg, bid) treatment of peptic ulcer in 23 cases and cimetidine (1.0g / d) group of 26 patients for controlled study. Treatment were 6wk, assessed by endoscopy efficacy. The results showed that the effective rates of ulceration of pirenzepine and cimetidine were 61% (14/23) and 81% (21/26), respectively. The analgesic efficiencies of the two groups were 65% (15/23) and 33% (6/18), no statistical difference. Therefore, pirenzepine has a similar curative effect on peptic ulcer as cimetidine. Pirenzepine adverse reactions are dry mouth, blurred vision, etc., more than cimetidine group.