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黄酮醋酸(Flavone Acetic Acid,LM975,1以下简称FAA)是一种化学合成的黄酮类化合物。临床前研究表明FAA对于许多移植性肿瘤,特别是实体瘤,具有明显的抑制活性。与一般细胞毒药物比较,FAA化学结构新颖、表现出不同的抗瘤谱与毒副作用。目前FAA已在美国和欧洲进入Ⅰ期和Ⅱ期临床研究。一、FAA的合成路线 FAA的合成路线如下图。二、FAA的抑瘤活性动物试验表明,FAA抗瘤谱异常,抑制实体瘤的活性显著,对于移植性结肠腺癌38、07/A、51、10A、结肠癌26、黑色素瘤B16、胰腺管癌02、03、乳腺癌16/C/adr、M 5076卵
Flavone Acetic Acid (LM975, hereinafter referred to as FAA) is a chemical synthesis of flavonoids. Preclinical studies have shown that FAA has significant inhibitory activity against many transplanted tumors, especially solid tumors. Compared with the general cytotoxic drugs, FAA chemical structure of novel, showing different anti-tumor spectrum and side effects. The FAA has now entered phase I and phase II clinical studies in the United States and Europe. First, FAA synthetic route FAA synthetic route as shown below. Second, FAA antitumor activity Animal experiments showed that FAA antitumor spectrum abnormalities, inhibition of solid tumor activity was significant for the transplant colon adenocarcinoma 38,07 / A, 51,10A, colon cancer 26, melanoma B16, pancreatic duct Cancer 02,03, breast cancer 16 / C / adr, M 5076 eggs