不孕不育已成为困扰全世界许多育龄夫妇的一个重要问题。在不孕不育原因中,男性约占40％,女性约占40％,双方约占10％～20％,但仍有10％～15％原因不明。据报道,世界范围内近50年来男性精子密度下降了40％～50％,同时作者也指出此结果存在偏倚,尚需进一步研究证实。尽管如此,男性生殖健康问题越来越引起人们关注。加强对男性不育的研究已成为全世界男科学家的一项紧迫任务。许多男性不育与遗传因素有关,近几年,随着分子生物学技术的发展, Infertility has become an important issue that plagues many couples of childbearing age around the world. In infertility reasons, about 40% of men, about 40% of women, both about 10% to 20%, but still 10% to 15% of the reasons unknown. It is reported that the world sperm density in the past 50 years decreased by 40% to 50%, while the authors also pointed out that the results of bias, still need further study confirmed. Nevertheless, the issue of male reproductive health is drawing more and more attention. Strengthening research on male infertility has become an urgent task for male scientists all over the world. Many male infertility and genetic factors, in recent years, with the development of molecular biology technology,