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包涵体肌炎(IBM)一个显著的特点是免疫抑制剂不能控制肌无力的进展。这对单核细胞浸润在IBM病程中的作用提出了疑问。本文对8名治疗6～24个月的IBM患者治疗前后肌肉活检发现以及临床反应和血清CK水平进行了比较。 8名患者符合IBM临床及组织学诊断标准。确诊后给予泼尼松每日100mg,持续4周。然后改为隔日疗法,每次100mg,至少6个月。治疗后再取肌肉活检。采用修改的医学研究委员会标准定患者的平均肌肉评分(AMS),做了伤残功能评分,测定了血
A notable feature of inclusion body myositis (IBM) is that immunosuppressive agents do not control the progression of muscle weakness. This questions the role of monocyte infiltration in the course of IBM. This article compares the findings of muscle biopsies and clinical responses and serum CK levels in 8 IBM patients 6 to 24 months before and after treatment. Eight patients met IBM clinical and histological diagnostic criteria. After the diagnosis of prednisone 100mg daily for 4 weeks. Then change to alternate therapy every 100mg for at least 6 months. After treatment and then take muscle biopsy. The average Muscular Score (AMS) of patients according to the revised Medical Research Council criteria was used to score disability scores and blood