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目的观察出生季节对新生儿筛查促甲状腺素水平及先天性甲状腺功能低下发病率的影响。方法选择1 800例新生儿,按季节划分为春季组、夏季组、秋季组、冬季组。对1 800例新生儿促甲状腺素水平进行筛查,对初步确定为阳性的患儿再次测定其血清游离三碘甲状腺原氨酸(FT3)水平、四碘甲状腺原氨酸(FT4)水平、促甲状腺素(TSH)水平。对比4组男性、女性筛选阳性率和新生儿先天性甲状腺功能低下发病率。结果冬季出生的新生儿结果呈阳性者居多,其初次阳性筛选率高于其他季节出生新生儿,差异均有统计学意义(P<0.05);不同季节出生新生儿先天性甲状腺功能低下发病率比较差异无统计学意义(P>0.05)。结论出生季节对新生儿先天性甲状腺功能低下发病率并无显著影响,但冬季出生的新生儿初筛促甲状腺素水平呈阳性者显著多于其他季节。
Objective To observe the influence of birth season on neonatal screening for thyroxine and congenital hypothyroidism. Methods A total of 1 800 newborns were selected and divided into spring group, summer group, autumn group and winter group according to the season. Thyrotropin levels of 1,800 newborns were screened and serum levels of free triiodothyronine (FT3), tetraethionine (FT4), and progesterone were again determined in children initially identified as positive Thyroid hormone (TSH) levels. Comparing the four groups of male and female screening positive rate and neonatal congenital hypothyroidism incidence. Results The number of newborn babies born in winter was mostly positive, and the first positive screening rate was higher than that of newborn babies born in other seasons (P <0.05). The incidence of congenital hypothyroidism among newborns born in different seasons The difference was not statistically significant (P> 0.05). Conclusion The birth season had no significant effect on the incidence of congenital hypothyroidism in newborns, but the neonatal neonates born in winter had significantly higher levels of thyroxine compared with other seasons.