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近年来,前列腺癌发病率呈明显的上升趋势。前列腺癌的早期诊断在前列腺癌的诊治中占有重要地位,然而目前广泛应用于前列腺癌诊断的方法却不具备高特异性和灵敏性。本综述介绍了4种前列腺癌的检测方法,PCA3与TMPRSS2:ERG,Kallikrein基因家族,磁共振显像引导下的前列腺活检术(MRGB),斯德哥尔摩3模型(STHLM3 model)。这4种方法都是基于分子生物学的检测方法,无论从特异性,灵敏性,还是简便快捷经济的角度,都具有明显优于传统检测方式的特点,以期实现前列腺癌的精准诊断。
In recent years, the incidence of prostate cancer showed a clear upward trend. The early diagnosis of prostate cancer plays an important role in the diagnosis and treatment of prostate cancer. However, the methods widely used in the diagnosis of prostate cancer do not possess high specificity and sensitivity. This review describes the detection of four prostate cancers, the PCA3 and TMPRSS2: ERG and Kallikrein gene families, magnetic resonance imaging-guided prostate biopsy (MRGB), and the STHLM3 model. These four methods are based on molecular biology detection methods, both in terms of specificity, sensitivity, or simple and quick economic point of view, have significantly better than the traditional detection methods, in order to achieve accurate diagnosis of prostate cancer.