论文部分内容阅读
本文观察烧伤及其修复过程中大鼠血浆、脾组织、腹腔巨噬细胞中cAMP、cGMP以及血浆PGF_2含量变化及其与烧伤免疫调整的关系。结果表明:烧伤鼠血浆中cAMP、PGE_2含量明显增高。(对照组cAMP值24.65±4.59pmol/ml,PGE_2值309.38±77.6(?)pg/ml,而烧伤鼠cAMP值36.58±2.74pmol/ml,PGE_2含量937.50±102.91pg/ml,P值分别为<0.05和<0.01),脾组织和巨噬细胞中cAMP值亦增高,而应用中药石膏后烧伤鼠血浆cAMP、PCE_2值明显下降(cAMP值22.49±1.56;PGE_2值478.13±85.05),脾组织和巨噬细胞中cAMP含量亦低于对照组值;同时,血浆,脾组织及巨噬细胞中cAMP/cGMP比值亦出现相应的变化。因此,作者推论,cAMP、cGMP、PGE_2可能参与烧伤时机体的免疫调节。中药石膏的作用可能通过Ca~(++)加强cGMP的作用,抑制cAMP、PGE_2的合成而增强免疫功能的。
In this paper, we observed the changes of cAMP, cGMP and PGF 2 levels in rat plasma, spleen and peritoneal macrophages during burn and repair, and their relationship with burn immunity. The results showed that the contents of cAMP and PGE_2 in burn rats were significantly increased. (P <0.01). The values of cAMP in control group were 24.65 ± 4.59pmol / ml, 309.38 ± 77.6 (?) Pg / ml in PGE_2, 36.58 ± 2.74pmol / ml in burn rat and 937.50 ± 102.91pg / ml in PGE_2, 0.05, <0.01). The cAMP value in spleen tissue and macrophages also increased. However, the plasma cAMP and PCE_2 values decreased significantly after burn with plaster of Chinese medicine (cAMP 22.49 ± 1.56; PGE 2 478.13 ± 85.05) The level of cAMP in macrophages was also lower than that in control group. Meanwhile, the ratio of cAMP / cGMP in plasma, spleen and macrophages also changed accordingly. Therefore, the authors infer that cAMP, cGMP, PGE_2 may be involved in the body’s immune regulation during burn injury. The role of traditional Chinese medicine gypsum may be through Ca ~ (++) to enhance the role of cGMP, inhibit the synthesis of cAMP, PGE_2 and enhance immune function.