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目的:通过测量收缩功能正常的冠心病患者择期经皮冠状动脉介入治疗(PCI)术前、术后血氨基末端脑钠肽前体(NT-proBNP)浓度的变化,探讨择期PCI对NT-proBNP浓度的影响及可能机制。方法:行择期PCI的冠心病患者60例,分别检测PCI术前、术后24h内血NT-proBNP、肌酸激酶同工酶(CK-MB)及肌钙蛋白-T(cTn-T),同时分析PCI术前血NT-proBNP浓度与冠状动脉病变间的关系。结果:择期PCI术后血NT-proB-NP浓度降低,lg(NT-proBNP)从术前的(2.68±0.46)ng/L降低到(2.53±0.41)ng/L,两者比较差异有统计学意义(P<0.01),而择期PCI术前术后CK-MB、cTn-T浓度无明显变化;择期PCI术前血NT-proBNP浓度随着冠状动脉受累支数、冠状动脉狭窄程度的加重而升高。结论:收缩功能正常的冠心病患者择期PCI可降低血NT-proBNP浓度,其机制可能与心肌缺血改善有关。
Objective: To evaluate the changes of NT-proBNP concentration before and after percutaneous coronary intervention (PCI) in patients with coronary artery disease (PTC) with normal systolic function and to evaluate the effect of elective PCI on NT-proBNP Effect of concentration and possible mechanism. Methods: Sixty patients with coronary artery disease undergoing elective PCI were enrolled in this study. Serum levels of NT-proBNP, CK-MB and cTn-T were measured before and 24 h after PCI. At the same time, the relationship between NT-proBNP concentration and coronary artery lesion was analyzed before PCI. Results: The concentration of NT-proBNP decreased and the lg (NT-proBNP) decreased from (2.68 ± 0.46) ng / L to (2.53 ± 0.41) ng / L preoperatively after PCI) (P <0.01). However, there was no significant change of CK-MB and cTn-T concentration in preoperative and postoperative PCI. The concentration of NT-proBNP in preoperative PCI with the increase of coronary artery involvement and the degree of coronary artery stenosis And rise. Conclusion: Elective PCI can reduce the concentration of NT-proBNP in patients with normal systolic coronary artery disease. The mechanism may be related to the improvement of myocardial ischemia.