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目的：研究苯海拉明对氯氮平所致流涎副作用的疗效。方法：女性５０例（精神分裂症４８例，躁狂症２例），服氯氮平（１５０～５２５ｍｇ／ｄ）治疗后，均出现流涎副作用，每晚口服苯海拉明５０ｍｇ治疗，１０ｄ为一个疗程。结果：苯海拉明治疗氯氮平所致流涎的有效率达１００％，起效快，无其他副作用。结论：苯海拉明能有效治疗氯氮平所致流涎症状。
Objective: To study the curative effect of diphenhydramine on the side effects of drool due to clozapine. Methods: Fifty female patients (48 schizophrenia patients and 2 manic patients) were treated with clozapine (150-525 mg / d). Side effects were observed after oral administration of diphenhydramine 50 mg daily for 10 days A treatment. Results: Diphenhydramine treatment of cloison-drug-induced salivation efficiency of 100%, rapid onset, no other side effects. CONCLUSION: Diphenhydramine is effective in treating symptoms of salivation caused by clozapine.