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目的:观察依那普利与阿托伐他汀联合治疗糖尿病肾病的临床效果。方法:将我院在2015年4月-2017年1月期间收录的糖尿病肾病患者中随机抽取76例作为观察对象,将其平均分配为对照组(n=38)和观察组(n=38)。对照组患者单独给予依那普利治疗,观察组患者给予依那普利与阿托伐他汀联合治疗;观察比较两组患者治疗前后的各项指标变化情况。结果:两组患者治疗后的FPG、2h PG、Hb Alc、SBP、DBP、UAER、Scr和Ccr指标均明显改善,组间数据存在显著差异,(P<0.05);观察组患者治疗后UAER、Scr和Ccr指标的改善情况优于对照组,组间数据存在显著差异(P<0.05)。结论:给予糖尿病肾病患者使用依那普利和阿托伐他汀,可有效稳定患者血糖水平,维护肾功能,可在临床上广泛运用。
Objective: To observe the clinical effect of enalapril combined with atorvastatin on diabetic nephropathy. Methods: A total of 76 patients with diabetic nephropathy who were included in our hospital from April 2015 to January 2017 were randomly divided into the control group (n = 38) and the observation group (n = 38) . Patients in the control group were treated with enalapril alone, and patients in the observation group were given enalapril combined with atorvastatin. The changes of each index before and after treatment in both groups were observed and compared. Results: The indexes of FPG, 2h PG, Hb Alc, SBP, DBP, UAER, Scr and Ccr in both groups were significantly improved after treatment, with significant difference between the two groups (P <0.05) The improvement of Scr and Ccr index was better than that of control group, there was significant difference between the two groups (P <0.05). Conclusion: The use of enalapril and atorvastatin in patients with diabetic nephropathy can effectively stabilize the blood glucose level and maintain renal function, which can be widely used clinically.