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利用本研究室构建的小鼠高血压模型,研究了大蓟水煎剂对高血压小鼠的降压作用以及对心脏、肾脏等器官的影响,同时检测对凝血的影响。结果表明:适量的大蓟水煎剂灌胃高血压模型小鼠,可显著降低血压至近正常值;大蓟水煎剂对心、肝、肾、脾、胸腺等的脏器体重比无显著影响,但高血压组肾脏和心脏组织细胞密度增大,肾小囊显著变小,治疗组肾脏中肾小囊恢复近正常值,肾脏和心脏组织细胞密度基本恢复正常;大蓟水煎剂治疗的小鼠凝血时间显著缩短。结论:适量的大蓟水煎剂灌胃高血压模型小鼠具有显著降压效应,对心脏和肾脏等内脏器官有较好的保护作用;大蓟增强凝血能力,而且与剂量成正相关性,因此用药量要适度。
Using the mouse model of hypertension developed in our lab, we studied the antihypertensive effect of Dachui decoction on hypertensive mice and its effects on the heart, kidney and other organs. The results showed that: moderate thistle decoction instillation of hypertensive mice, can significantly lower blood pressure to near normal values; thistle Decoction of heart, liver, kidney, spleen, thymus and other organs weight ratio had no significant effect , But the density of kidney and heart tissue in hypertensive group increased and the size of renal cysts decreased significantly. The renal cystic vesicles recovered nearly normal in treatment group and the density of kidney and heart tissue returned to normal. Coagulation time was significantly shorter in mice. CONCLUSION: The moderate thistle-decoction-induced hypertensive mice have a significant antihypertensive effect, which has a good protective effect on the visceral organs such as heart and kidney. The thistle increases the blood clotting capacity and is positively correlated with the dose Medication should be moderate.