Chemical proteomics: terra incognita for novel drug target profiling

来源 :癌症:英文版 | 被引量 : 0次 | 上传用户:xiaogege0451
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
The growing demand for new therapeutic strategies in the medical and pharmaceutic fields has resulted in a pressing need for novel druggable targets.Paradoxically,however,the targets of certain drugs that are already widely used in clinical practice have
其他文献
The advent of targeted therapies, combined with an unsustainable rate of failure in oncology drug development, has resulted in a number of new approaches to cli
The bones are the most common sites of breast cancer metastasis. Upon arrival within the bone microenvironment, breast cancer cells coordinate the activities of
Oncolytic herpes simplex virus (HSV) can replicate in and kill cancer cells without harming normal tissue. G47Δ is a third-generation HSV vector. In this study
本文通过对更新一代的"P2P+CDN"流媒体平台进行了较为详细的阐述,分析了P2P与CDN系统融合的主要优势,顺应了电信运营商既要利用有效的CDN平台又要管理无序P2P技术的需求,为进一
Neoadjuvant chemotherapy(NACT),which can reduce the size and therefore increase the resectability of tumors,has recently evolved as a treatment for locally adva
摘 要:目标设置可作为一种教学模式应用于高校羽毛球的教学中,通过目标设置训练可以较好地促进学生技战术学习的自我监控,并且可以使学生在学习中能够有的放矢,促使其较快掌握羽毛球基本技术动作与战术要求,让基本技术更稳定。任何一种教学模式都不是万能的,目标设置的教学模式同样可能会出现一些问题,针对这些在实践中可能出现的问题提出些许建设性策略。   关键词:高校;羽毛球教学;目标设置模式  近年来,
摘要:随着新一轮基础教育课程改革的推行,对体育教师的要求就更高了,而实际实施过程中却可以看到另一番相反情形,就其实质还是因为对体育课的理解、对教学媒介的实施者和参与者关系没有看清,本文试从这两个方面来分析和论证,以期对课程改革有一定明辨作用。  关键词:课程改革 体育教师 师生关系    师者,所以传道授业解惑者。古人对老师的定义在今天看来仍然有很大的意义。体育教师也不应例外,尤其是在中小学基础教
从事初级日语教学的人或许都有这种体验,学生在学习语音发音时,扮段假名往律总是发不好,有的老师干脆就这样解释:这个元音的发音既不是汉语的“欧”,也不是“凹“,而是介于二者之间
Our previous study revealed that spaceflight induced biological changes in human cervical carcinoma Caski cells. Here, we report that 48A9 cells, which were sub
The developments of medicine always follow innovations in science and technology.In the past decade,such innovations have made cancer-related targeted therapies