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慢性肉芽肿病(CGD)是一种致死性肉芽肿疾病,由于先天性的缺陷,患者的吞噬细胞不能杀死己吞噬的微生物而发病,主要见于儿童。确诊 CGD 的方法是用大戟二萜醇醋酸盐刺激四唑氮蓝(NBT)试验,这一试验对患者的中性白细胞不染色。现在己知 CGD 无杀伤微生物的能力是由于吞噬细胞中细胞色素 b 的缺陷,并与遗传性有关。目前对 CGD 尚无良好的防治方法。
Chronic granulomatous disease (CGD) is a fatal granulomatous disease, the patient’s phagocytes can not kill the phagocytosis of microorganisms due to a congenital defect, mainly in children. The method of diagnosing CGD is to stimulate the tetrazolium nitrogen blue (NBT) test with the Inventiol acetate, a test that does not stain the patient’s neutrophils. It is now known that the ability of CGDs to kill non-lethal microorganisms is due to the defects of cytochrome b in phagocytes and is associated with heredity. There is currently no good control over CGD.