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目的:探讨认知矫正（functional remediation）对稳定期双相障碍患者的疗效。方法:利用计算机随机分组法，将双相障碍患者按照1∶1比例分为认知矫正组（n n = 39）和常规治疗组（n n = 42），并给予12周干预，观察认知矫正组和常规治疗组患者情绪识别、社会和认知功能的疗效差异；分别采用汉密尔顿抑郁量表（Hamilton Depression Rating Scale-17，HDRSn 17）、杨氏躁狂量表（Young Mania Rating Scale， YMRS）、 Bell-Lysaker情绪识别任务（Bell-Lysaker Emotion Recognition Task， BLERT）、功能测验简版（Functioning Assessment Short Test， FAST）、精神分裂症认知功能评估成套测验［Measurement and Treatment Research to Improve Cognition in Schizophrenia（MATRICS）Consensus Cognitive Battery， MCCB］评估患者的情绪和社会及认知功能，采用重复测量方差分析方法比较2组相关变量指标的差异性和交互作用。n 结果:（1）2组基线人口学变量和临床变量差异无统计学意义；（2）认知矫正组BLERT负性情绪正确数干预前后变化值显著高于常规治疗组（n F=4.53，n P<0.05）；（3）认知矫正组FAST总分、职业功能、认知功能得分干预前后变化值显著高于常规治疗组（n F=8.15、7.94、10.93，均n P<0.05）；（4）认知矫正组连线测验-A［（41.2±10.2/50.4±6.0）分比（39.9±9.8/44.2±3.6）分］、符号编码［（41.8±5.6/52.5±7.4）分比（40.5±10.4/46.2±4.2）分］、词语学习［（41.2±4.2/51.7±4.2）分比（40.0±5.9/46.0±3.2）分］和持续操作测验［（41.7±11.1/51.4±5.8）分比（43.2±8.3/45.7±2.5）分］干预前后变化值显著高于常规治疗组（n F=5.35、4.94、8.77、10.56，均n P0.05); (2) The repeated-measures analyses revealed that FR group had greater improvement in the correct numbers of BLERT-negative emotional recognition compared to TAU group (n F=4.53, n P<0.05); (3) FR group showed greater improvements in the FAST total scores including occupational functioning and cognitive functioning compared to TAU group (n F=8.15, 7.94, 10.93, all n P<0.05); (4) FR group showed greater improvements in the T-scores for TMT-A (Trail Making Test-A), BACS-SC (Brief Assessment of Cognition in Schizophrenia: Symbol Coding subtest), HVLT-R (Hopkins Verbal Learning Test-Revised) and CPT (Continuous Performance Test) compared to TAU group [(41.2±10.2/50.4±6.0)n vs. (39.9±9.8/44.2±3.6), (41.8±5.6/52.5±7.4)n vs. (40.5±10.4/46.2±4.2), (41.2±4.2/51.7±4.2)n vs. (40.0±5.9/46.0±3.2), (41.7±11.1/51.4±5.8)n vs. (43.2±8.3/45.7±2.5), n F=5.35, 4.94, 8.77, 10.56, alln P<0.05].n Conclusions:These findings suggest that FR is a feasible and promising intervention for negative emotional recognition, occupational functioning, ability of verbal learning, attention and information-processing for euthymic patients with BD.