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目的探讨白细胞介素(IL)-18与多囊卵巢综合征(PCOS)患者自然流产的关系。方法选取2012年8月-2013年9月在该院就诊的PCOS患者80例为PCOS组,其中妊娠成功60例,妊娠在28周前自行终止且胎儿体重<1 000 g者18例为自然流产组,正常足月妊娠者42例为正常足月妊娠组。另选取同期在该院门诊健康体检的女性47例为对照组。检测各组研究对象血清IL-18水平,并分析其与妊娠结局、体重指数(BMI)、基础血清促卵泡生成素(FSH)、促黄体生成素(LH)及血清睾酮(T)等指标的相关性。结果 PCOS组血清IL-18水平高于对照组(P<0.05)。PCOS患者IL-18与BMI、T呈正相关(r=0.288,0.249,P<0.05),与其他检测指标无相关性(P>0.05)。PCOS自然流产组血清IL-18水平低于PCOS正常足月妊娠组(P=0.027)。结论 IL-18水平与PCOS发病相关,并且对其妊娠结局起到保护性作用。
Objective To investigate the relationship between interleukin (IL) -18 and spontaneous abortion in patients with polycystic ovary syndrome (PCOS). Methods Eighty PCOS patients in our hospital from August 2012 to September 2013 were selected as the PCOS group. Among them, 60 cases were successful in pregnancy, 18 cases terminated spontaneous pregnancy before 28 weeks, and 18 cases with fetal weight <1,000 g were spontaneous abortion Group, normal full-term pregnancy in 42 cases of normal term pregnancy group. Another select the same period in the hospital outpatient physical examination in 47 women as a control group. The levels of serum IL-18 in each group were detected and compared with those of pregnancy outcome, body mass index (BMI), basal serum follicle-stimulating hormone (FSH), luteinizing hormone (LH) and serum testosterone Correlation. Results The level of serum IL-18 in PCOS group was higher than that in control group (P <0.05). There was a positive correlation between IL-18 and BMI, T in patients with PCOS (r = 0.288, 0.249, P <0.05), but no correlation with other test parameters (P> 0.05). Serum levels of IL-18 in spontaneous abortion group were lower than those in PCOS normal term pregnancy group (P = 0.027). Conclusion The level of IL-18 is associated with the pathogenesis of PCOS and plays a protective role in its pregnancy outcome.