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用金刚烷与乙腈、20%发烟硫酸“一锅法”反应制得1-乙酰胺基金刚烷,再经氢氧化钠水解、与盐酸成盐制得抗病毒药盐酸金刚烷胺,总收率约82%。
Adamantane and acetonitrile, 20% oleum “one-pot method” reaction 1-acetamido adamantane, and then hydrolyzed with sodium hydroxide, and hydrochloric acid salt obtained in the antiviral amantadine hydrochloride, The total yield of about 82%.