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目的:检测并比较结直肠癌及结直肠正常组织内淋巴管密度(LVD)和血管内皮生长因子(VEGF-C)的表达,并计数结直肠癌组织中淋巴管内癌栓(LVI),探讨其意义。方法:免疫组化法检测结直肠癌及相应的正常结直肠组织中LVD及VEGF-C的表达,计数结直肠癌组织LVI。结果:结直肠癌组织中的LVD明显高于正常结直肠组织,P=0.000。结直肠癌的LVD与LVI(P=0.001)及淋巴结转移(P=0.047)密切相关。LVI与TNM分期(P=0.017)及淋巴结转移(P=0.006)密切相关。结直肠癌组织中VEGF-C表达显著高于正常结直肠组织(P=0.000),且与肿瘤的TNM分期(P=0.029)及淋巴结转移(P=0.023)密切相关。结论:淋巴管的形成在结直肠癌的发生发展过程中起重要的作用。LVI及VEGF-C的表达可预测结直肠癌的侵袭性。
Objective: To detect and compare the expression of lymphatic vessel density (LVD) and vascular endothelial growth factor (VEGF-C) in colorectal cancer and normal colorectal tissues and to count the lymphatic tumor thrombus (LVI) in colorectal cancer tissues significance. Methods: The expression of LVD and VEGF-C in colorectal cancer and corresponding normal colorectal tissues was detected by immunohistochemistry and the colorectal cancer LVI was counted. Results: LVD in colorectal cancer tissues was significantly higher than that in normal colorectal tissues (P = 0.000). The LVD of colorectal cancer was closely related to LVI (P = 0.001) and lymph node metastasis (P = 0.047). LVI was closely related to TNM staging (P = 0.017) and lymph node metastasis (P = 0.006). The expression of VEGF-C in colorectal cancer was significantly higher than that in normal colorectal tissues (P = 0.000), which was closely related to TNM stage (P = 0.029) and lymph node metastasis (P = 0.023). Conclusion: The formation of lymphatic vessels plays an important role in the development of colorectal cancer. The expression of LVI and VEGF-C predicts the aggressiveness of colorectal cancer.