由于硫代嘌呤甲基转移酶(TPMT)是一种受基因调控和易变的细胞内酶,巯基嘌呤 (6-MP)的细胞毒性受其影响较大,而硫鸟嘌呤(6-TG)很少受TPMT的影响,所以 6-T G可能是一种更为可靠的药物,体内 TPMT活性较高的病人使用6-TG效果肯定要好。一组患急性淋巴细胞白血病(ALL)儿童中,通过药物动力学对照试验试图对这两种药物的适用性作出评价,选择二次缓解或即将缓解的 Because thiopurine methyltransferase (TPMT) is a genetically regulated and mutable intracellular enzyme, the cytotoxicity of thiopurine (6-MP) is greatly affected, whereas thioguanine (6-TG) 6-TG may be a more reliable drug and is less likely to be affected by TPMT. 6-TG in patients with higher TPMT activity in vivo is definitely better. In a group of children with acute lymphoblastic leukemia (ALL), pharmacokinetic control trials attempted to evaluate the suitability of these two drugs and choose either secondary or imminent