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哌唑嗪是一个口服有效的突触后膜α受体阻断剂。它选择性地扩张阻力血管和容量血管,减轻心脏的前、后负荷,增加心输出量,改善心脏功能,对慢性心衰具有良好疗效。如果开始用量过大或增加剂量过快,则易出现体位性低血压,并由此引起“首剂反应综合症”及其它不良反应。近来还发现,某些患者对哌唑嗪也可产生快速耐受。为防止不良反应发生,服用时宜从小剂量开始或睡前服药,并适当地增加病人的食盐摄入。
Prazosin is an orally potent post-synaptic alpha receptor blocker. It selectively expands resistance blood vessels and volume of blood vessels, reduce the heart before and after the load, increase cardiac output, improve cardiac function, has a good effect on chronic heart failure. If you start overdose or increase the dose too fast, prone to orthostatic hypotension, and thus cause the “first dose response syndrome” and other adverse reactions. It has also recently been found that some patients also develop rapid tolerance to prazosin. To prevent the occurrence of adverse reactions, taking it from the beginning of small doses or medication before going to bed, and appropriate to increase the patient’s salt intake.