铜兰蛋白是人体血浆中一种含铜的糖蛋白,主要存在于α_2—球蛋白部分,可以氧化对苯二胺,具有胺氧化酶的作用。在胶原聚合成纤维的交联反应中,此酶以铜离子为辅基,能促进 链中赖氨酸的胺基氧化,最后导致胶原纤维的形成。故血清中铜兰蛋白活性增高标志着胶原聚合成纤维过程的加剧。医科院卫研所、武医等报导矽肺患者血清铜兰蛋白比正常 Copper lanolin is a copper-containing glycoprotein in human plasma, which is mainly found in the α_2-globulin part, which can oxidize p-phenylenediamine and has the function of amine oxidase. In the collagen polymerization into fiber cross-linking reaction, the enzyme to copper ions as a cofactor, can promote amino acid oxidation of lysine in the chain, and finally lead to the formation of collagen fibers. Therefore, the increased activity of cerulein in serum marked the aggravation of collagen polymerization into fibers. Medical Institute of Wei, Wu and other reports of serum ceruloplasmin patients than normal