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目的研究氟哌噻吨美利曲辛联合个性化心理干预治疗对慢性阻塞性肺疾病(COPD)合并抑郁患者焦虑抑郁情绪、肺功能及生活质量的影响。方法选取我院从2015年4月至2016年3月收治的100例COPD合并抑郁患者,随机分为观察组(50例)和对照组(50例);两组均予以COPD的相关治疗,此外对照组采取氟哌噻吨美利曲辛进行治疗,观察组在此基础上采取为个性化心理干预治疗,将两组患者的肺功能情况、汉密尔顿焦虑量表(HAMA)评分与汉密尔顿抑郁量表(HAMD)评分、生活质量进行对比分析。结果两组患者治理前肺功能、焦虑抑郁评分及生活质量评分,组间无明显差异(P>0.05);治疗后观察组的HAMA评分与HAMD评分低于对照组,生活质量评分高于对照组且肺功能各项指标均优于对照组(P<0.05)。结论 COPD合并抑郁患者应用氟哌噻吨美利曲辛联合个性化心理干预治疗可有效缓解患者的抑郁焦虑情绪,改善患者的肺功能和生活质量,因此值得在临床上推广应用。
Objective To investigate the effects of flupentixol and melitrace combined with personalized psychological intervention on anxiety and depression, pulmonary function and quality of life in patients with chronic obstructive pulmonary disease (COPD) and depression. Methods One hundred patients with COPD with depression who were admitted to our hospital from April 2015 to March 2016 were randomly divided into observation group (50 cases) and control group (50 cases). Both groups were given COPD related treatment. In addition, The control group took flupentixol and melitracen for treatment. On the basis of this, the observation group took individualized psychological intervention to treat the pulmonary function, Hamilton Anxiety Scale (HAMA) score and Hamilton Depression Rating Scale (HAMD) score, quality of life for comparative analysis. Results Before treatment, the lung function, anxiety and depression scores and quality of life scores of the two groups were not significantly different (P> 0.05). After treatment, the HAMA score and HAMD score of the observation group were lower than those of the control group, and the quality of life scores were higher than those of the control group The indexes of pulmonary function were superior to those of the control group (P <0.05). Conclusion The combination of flupentixol and melitracen combined with personalized psychological intervention in patients with COPD and depression can effectively alleviate the depression and anxiety of patients and improve the lung function and quality of life of patients with COPD. Therefore, it is worth popularizing and applying in clinic.