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目的观察并对比NP方案(长春瑞滨联合顺铂)和PF方案(顺铂+5-Fu)治疗晚期食道癌的临床疗效。方法将58例晚期食道癌患者随机分为NP方案组和PF方案组,每组29例。NP方案组采用长春瑞滨联合顺铂化疗,PF组采用顺铂联合5-Fu化疗,以3周为一个化疗周期,2个周期后评价两组疗效及安全性。结果 NP方案组有效率为48.27%(14/29),PF方案组有效率为37.93%(11/29),NP方案组有效率明显高于PF方案组,差异具有统计学意义(P<0.05)。主要毒副反应为骨髓抑制和胃肠道反应,但均可耐受,两组在骨髓抑制率方面差异无统计学意义,但消化道反应方面PF组明显高于NP组,差异具有统计学意义(P<0.05)。结论 NP方案治疗晚期食道癌化疗,无论在临床疗效还是毒副作用方面,均明显优于PF方案;NP方案疗效确切,毒副作用可耐受,值得临床推广应用。
Objective To observe and compare the clinical efficacy of NP regimen (vinorelbine plus cisplatin) and PF regimen (cisplatin + 5-Fu) in the treatment of advanced esophageal cancer. Methods 58 patients with advanced esophageal cancer were randomly divided into NP and PF regimen group, 29 cases in each group. NP regimen with vinorelbine combined with cisplatin chemotherapy, PF group with cisplatin combined with 5-Fu chemotherapy, three weeks as a chemotherapy cycle, two cycles after the evaluation of efficacy and safety of the two groups. Results The effective rate of NP group was 48.27% (14/29), while that of PF group was 37.93% (11/29). The effective rate of NP group was significantly higher than that of PF group (P <0.05) ). The main toxicities were myelosuppression and gastrointestinal reaction, but both were tolerable. There was no significant difference in the bone marrow suppression rate between the two groups, but the PF group was significantly higher than the NP group in the digestive tract reaction, the difference was statistically significant (P <0.05). Conclusion NP regimen is superior to PF regimen in the treatment of advanced esophageal cancer chemotherapy, both in terms of clinical efficacy and side effects. NP regimen has definite curative effect and tolerable toxic and side effects and is worthy of clinical application.