本文报道了体外溶出速度有显著差异的泼尼松与醋酸泼尼松片剂的体内比较试验。结果表明:醋酸泼尼松片剂之间及泼尼松与醋酸泼尼松片剂之间均无体内外相关关系。由于三个样品体内血峰浓度、曲线下面积、峰时均表示有相等的生物利用度,因此,作者认为目前采用的泼尼松片溶出速度技术一般地还不能用来充分预示体内生物利用度参数。 In this paper, in vivo comparative studies of prednisone and prednisone acetate tablets with significant differences in in vitro dissolution rates were reported. The results showed that there was no in vivo and in vitro correlation between prednisone acetate tablets and prednisone and prednisone acetate tablets. Because of the peak plasma concentration, the area under the curve, and the peak, all three samples showed equal bioavailability, the authors concluded that the current prednisone strip dissolution rate technique has not generally been used to adequately predict in vivo bioavailability parameter.