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本文报导用秋水仙硷治疗5例Behcet氏病取得了满意的结果.在实验室内秋水仙硷显示能影响各种白细胞的功能,低血浆浓度的秋水仙硷可抑制多形核白细胞的趋化性.Behcet氏病表现为过度反应性细胞炎症性反应,可能由于多形核白细胞趋化活性增强.因此在理论上秋水仙硷用于治疗Behcet氏病可能是一种理想的药物.5例患者的皮肤表现为结节红斑样损害、阿夫他口腔炎、生殖器糜烂、毛囊炎样损害、伴有或无眼部症状.近1—8年曾用非激素类抗炎症性制剂或与类固醇激素治疗,疗效均不理想,因此开始采用每日口服1毫克秋水仙硷治疗,不到一个月的时间内皮肤与眼部症状有了显
This article reports satisfactory results with colchicine treatment of 5 cases of Behcet’s disease in the laboratory show that colchicine can affect a variety of leukocyte function, low plasma concentration of colchicine can inhibit polymorphonuclear leukocyte chemotaxis Behcet’s disease is characterized by an overreactive cellular inflammatory response that may be due to enhanced chemotactic activity of polymorphonuclear leukocytes, so colchicine may theoretically be an ideal drug for the treatment of Behcet’s disease.5 Five patients The skin showed nodular erythema-like damage, phlox stomatitis, genital erosion, folliculitis-like damage, with or without eye symptoms. Nearly 1-8 years had used non-hormonal anti-inflammatory agents or with steroid hormones Treatment, efficacy are not ideal, so began using daily oral 1 mg colchicine treatment, less than a month’s time the skin and eye symptoms were significantly