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目的：探讨免疫毒素对裸鼠移植人肺腺癌的抗癌机理与形态变化的关系。方法：对ＣＭＵ１５Ａ—ＴＣＳ治疗后的肺腺癌标本进行了光电镜观察。结果：ＣＭＵ１５Ａ—ＴＣＳ对肺腺癌有明显的靶向杀伤作用，受损靶瘤细胞的分布与用药途径有关，肿瘤内用药的杀伤效果优于腹腔用药；免疫毒素作用于细胞内核糖体，但在超微形态结构上很难确认出核糖体的病理改变，而以线粒体的病理变化出现的最早、最明显。结论：受损细胞内游离核糖体减少，粗面内质网数量明显减少且扩张，表面核糖体脱失等现象与天花粉蛋白的作用机理一致。
Objective: To investigate the relationship between the anti-cancer mechanism and morphology of human lung adenocarcinoma transplanted in nude mice. Methods: The specimens of lung adenocarcinoma after CMU15A-TCS treatment were observed by light and electron microscope. RESULTS: CMU15A-TCS had a significant targeted killing effect on lung adenocarcinoma. The distribution of damaged target tumor cells was related to the route of administration. The killing effect of intratumoral drug administration was better than that of intraperitoneal administration; immunotoxins acted on the cytoskeletal nuclear bodies, but It is difficult to confirm the pathological changes of ribosomes in the ultramicroscopic structure, but the earliest and most obvious pathological changes occur in mitochondria. CONCLUSION: The number of free ribosomes in injured cells is decreased, and the number of rough endoplasmic reticulum is significantly reduced and expanded. The surface ribosome loss is consistent with the mechanism of action of trichosanthin.