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目的 探索一氧化氮合成酶 (NOS)抑制剂对断裂周围神经再生的影响。方法 用 SD雄性大鼠 24只。在距梨状肌下缘 1cm处切断坐骨神经，远断端去除 4mm长，取硅胶管桥接两神经断端，并使其相距 4mm，随机分成硅胶管和腹腔注射两组。一组其右侧注入 10mg/kg亚硝基左旋精氨酸甲酯 (L-NAME)，左侧注入等量生理盐水作对照。另组用同等剂量 L-NAME改为腹腔注射 10d。每组分成二半，分别于术后 1、 2月取材，作组织学检测。结果 发现 L-NAME对周围神经的再生有明显的促进作用，而局部注射药较腹腔注射给药神经再生优。结论 L-NAME能促进周围神经再生。
Objective To explore the effect of nitric oxide synthase (NOS) inhibitor on peripheral nerve regeneration after fracture. Methods 24 SD male rats were used. The sciatic nerve was cut at 1 cm from the inferior edge of the piriformis. The distal part of the sciatic nerve was removed for 4 mm. The ends of the two nerves were bridged with silicone tubes and separated by 4 mm. They were randomly divided into two groups: silicone tube and intraperitoneal injection. A group of 10 mg / kg nitroso-L-arginine methyl ester (L-NAME) injected into the right side and an equal volume of physiological saline injected into the left side served as a control. The other group with the same dose of L-NAME into intraperitoneal injection 10d. Each group was divided into two halves, respectively, in January and February after surgery, for histological examination. The results showed that L-NAME has a significant role in promoting the regeneration of peripheral nerves, whereas local injection is more effective than intraperitoneal injection for nerve regeneration. Conclusion L-NAME can promote peripheral nerve regeneration.