[目的]分析、探讨鼻咽癌放疗中并发医院感染的临床特点与危险因素。[方法]回顾性分析221例鼻咽癌患者医院感染病例的临床资料。[结果]感染部位以下呼吸道为主(29.9%),引起感染的病原菌以革兰氏阴性菌为主(50.8%),真菌感染也占较大比例(31.1%),感染与住院天数、放疗类型、化疗、侵入性操作等危险因素有关。[结论]尽可能控制各种能引起的感染环节,减少医院感染的发生。 [Objective] To analyze and discuss the clinical features and risk factors of nosocomial infection in radiotherapy of nasopharyngeal carcinoma. [Methods] A retrospective analysis of 221 cases of nosopharyngeal cancer patients with nosocomial infection clinical data. [Results] The main respiratory tract was below respiratory tract (29.9%). Gram-negative bacteria was the most common pathogens (50.8%), fungal infections accounted for a large proportion (31.1%), infection and hospitalization days, , Chemotherapy, invasive operations and other risk factors. [Conclusion] As much as possible to control various aspects of infection can be caused to reduce the incidence of nosocomial infections.