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直到大约5年前女性类固醇仍是抑制泌乳的标准治疗。产褥期血栓栓塞的危险业已增加,因投以类固醇而进一步加重,故改用溴隐亭。此药通过阻止催乳素分泌达到迅速抑制泌乳作用,但因常有复发和副作用(恶心、呕吐和头晕)故需选择另一种具有同样疗效且持久抑制泌乳又易耐受的药物。 cyclofenil亦能抑制催乳素分泌。初步资料指出此药可有效减少产后泌乳。作者通过双盲试验比较cyclofenil和溴隐亭的临床作用及有关激素变化和对血液学、凝血及肝功能的影响。产后7天内开始给药每日两次共14天。13例每次接受300mg cyclofenil,11例接受2.5mg溴隐亭。记录主观症状、测定血浆催乳素、雌二醇和FSH的水平。血红蛋白、红细胞压积和红、白血
Female steroids remained the standard treatment for lactation until about 5 years ago. The risk of puerperal thromboembolism has increased due to cast steroids and further aggravate, so use bromocriptine instead. The drug suppresses rapid lactation by preventing prolactin secretion. However, due to frequent recurrent and side effects (nausea, vomiting and dizziness), the drug needs to be given another drug that has the same therapeutic effect and lasts for long-term suppression of lactation and tolerance. Cyclofenil also inhibits prolactin secretion. Preliminary data indicate that this medicine can effectively reduce postpartum lactation. The authors compared the clinical effects of cyclophenil with bromocriptine and its effects on hormonal changes and on hematology, coagulation, and liver function through a double-blind trial. The drug is administered twice daily for 14 days within 7 days after delivery. Thirteen patients received 300 mg cyclofenil each time and 11 patients received 2.5 mg bromocriptine. Subjective symptoms were recorded and plasma prolactin, estradiol and FSH levels were measured. Hemoglobin, hematocrit and red and white blood