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[目的]探讨甘利欣治疗结核药性肝功能损害的临床疗效。[方法]将2007.1~2009.12月诊断为抗结核药物性肝炎86例住院病人进行随机分为治疗组及对照组,前者使用甘利欣治疗,后者进行常规性治疗,对其疗效进行分析。[结果]结核药物性肝炎多发生在抗结核治疗的强化期间,使用甘利欣治疗后其临床症状改善显著,治疗1周、2周、3周分别复查肝功能丙氨基酸转移酶(ALT)指标下降显著,治疗组疗效明显优于对照组。[结论]使用甘利欣治疗药物性肝炎,对临床症状改善及肝功能恢复情况均有明显效果,且廉价物美,临床用药安全,病人容易接受。
[Objective] To explore the clinical efficacy of Glycyrrhizin in the treatment of drug-induced liver dysfunction in tuberculosis. [Methods] Eighty-six inpatients diagnosed with anti-tuberculosis drug-induced hepatitis from January 2007 to December 2009 were randomly divided into treatment group and control group. The former was treated with Glycyrrhizin, and the latter was treated routinely. The curative effect was analyzed. [Results] Tuberculosis drug-induced hepatitis mostly occurred during the enhancement of anti-TB treatment. The clinical symptoms improved significantly after treatment with Glycyrrhizin. The indexes of ALT decreased after 1 week, 2 weeks and 3 weeks of treatment Significantly, the treatment group was significantly better than the control group. [Conclusion] The use of Glycyrrhizin in the treatment of drug-induced hepatitis has obvious effect on the improvement of clinical symptoms and recovery of liver function, and is cheap and easy to use and safe for clinical use, and the patients are easy to accept.