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目的观察替吉奥和顺铂联用治疗胃癌的疗效和安全性。方法 50例胃癌患者,随机分成对照组与治疗组,每组患者各25例,对照组采用5-氟尿嘧啶联合顺铂治疗方案,5-氟尿嘧啶每天350mg/m2第1～5天泵入,顺铂每天30mg/m2,第1～5天泵入。治疗组采用替吉奥联合顺铂方案,每天给患者给予替吉奥30～50mg/次,2次/d,第1～21天给药,顺铂每天30mg/m2,第1～5天持续给药,每21d为一个周期,完成两个周期后对治疗效果进行分析。结果治疗组患者中,2例患者完全缓解,17例患者病情部分缓解,4例患者病情稳定,2例患者病情进展,治疗总有效率(CR+PR)为76%。结论替吉奥联合顺铂治疗胃癌较低,值得临床推广使用。
Objective To observe the efficacy and safety of treatment of gastric cancer with Gio and cisplatin. Methods Fifty patients with gastric cancer were randomly divided into control group and treatment group with 25 patients in each group. The control group was treated with 5-fluorouracil combined with cisplatin. The patients were treated with 5-fluorouracil 350 mg / Daily 30mg / m2, 1 to 5 days pump. Patients in the treatment group were treated with ticlopidine combined with cisplatin. Patients were given tirofiban 30 ~ 50mg / time, twice a day for 1 ~ 21 days, and cisplatin 30mg / m2 every day for the first 5 days Dosing, every 21d for a cycle, the completion of two cycles after the treatment effect analysis. Results In the treatment group, 2 patients were completely relieved, 17 patients were partially relieved, 4 patients were stable and 2 patients were in serious condition. The total effective rate (CR + PR) was 76%. Conclusion The treatment of gastric cancer by Giovanni combined with cisplatin is lower, which is worthy of clinical promotion.