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目的研究探讨p53蛋白与脑胶质瘤临床病理及预后的关系。方法采用以p53单克隆抗体通过免疫组织化学ABC方法,对45例脑胶质瘤术后石蜡包埋切片标本进行分析。结果45例脑胶质瘤p53蛋白的阳性表达32例,占71.1%,其中Ⅱ级、Ⅲ~Ⅳ级组、未复发组与Ⅰ级组、复发组相比较有显著差异性(P<0.01)。结论p53蛋白的异常表达主要位于细胞核内,与肿瘤分级及病人的预后有关。因此对p53蛋白表达阳性者成就尤其是强阳性者术后应进行辅助治疗,并长期随访。
Objective To investigate the relationship between p53 protein and the clinicopathology and prognosis of glioma. Methods 45 cases of glioma after operation by paraffin embedded sections were analyzed by immunohistochemical ABC method using p53 monoclonal antibody. Results The positive expression rate of p53 protein in 45 cases of gliomas was 32 (71.1%). There was significant difference between grade Ⅱ and Ⅲ ~ Ⅳ group, grade Ⅰ group and recurrence group (P < 0.01). Conclusion The abnormal expression of p53 protein is mainly located in the nucleus, which is related to tumor grade and the prognosis of patients. Therefore, the positive expression of p53 protein, especially strong positive postoperative patients should be adjuvant therapy, and long-term follow-up.