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目的 对 43例脑胶质瘤术后放疗后疗效观察 ,并对影响其预后的因素进行分析。方法 手术切除后经病理证实为脑胶质瘤 ,其中肉眼全切 11例 (2 5 6 % )。大部分切除 19例 (44 2 % )。部分切除13例 (30 2 % )。高能X线照射 ,肿瘤剂量DT40～ 6 0Gy ,常规分次照射。数据经随访获得。结果 43例总 5年生存率为 2 3 3%。其中低分级 (Kernohen分级法Ⅰ、Ⅱ级 )胶质瘤的 1、3、5年生存率分别为84 0 %、5 8 8%、42 1%。高分级 (Kernohen分级Ⅲ、Ⅳ级 )胶质瘤的 1、3、5年生存率分别为 83 3%、2 9 4%、12 5 %。两组 3、5年生存率差异有显著统计学意义 (P <0 0 1)。结论 病理分级为影响预后的主要因素 ,年龄、性别等未见有明显影响。
Objective To observe the curative effect of postoperative radiotherapy in 43 cases of glioma and to analyze the factors influencing its prognosis. Methods After the surgical resection, the pathology confirmed the glioma, of which 11 cases (2.56%) were totally resected by naked eyes. Most of the resection in 19 cases (44 2%). Partial resection in 13 cases (30 2%). High-energy X-ray irradiation, tumor dose DT40 ~ 60Gy, conventional fractionated irradiation. Data was obtained on follow-up. Results The total 5-year survival rate of 43 cases was 23.3%. The 1, 3, 5-year survival rates of low grade (Kernohen grade Ⅰ, Ⅱ grade) gliomas were 84 0%, 58 8% and 42 1%, respectively. The 1, 3, 5-year survival rates of high grade (Kernohen Grade III and IV) gliomas were 83.3%, 294% and 125%, respectively. There was a statistically significant difference in the 3 and 5-year survival rates between the two groups (P <0.01). Conclusion The pathological grade is the main factor affecting the prognosis, age, gender, no significant impact.