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目的:观察肥胖患者载脂蛋白M水平并探讨其与炎症因子的关系。方法:58例体重正常者和36例肥胖患者常规测量体重、身高,计算体重指数,抽取空腹静脉血检测血脂、血浆载脂蛋白M(apoM)、白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)。结果:肥胖患者血浆apoM、高密度脂蛋白胆固醇(HDL-C)降低(P<0.05),IL-6、TNF-α、CRP水平升高(P<0.05),肥胖患者血浆apoM与HDL-C正相关,血浆apoM与IL-6、TNF-α、CRP水平负相关。结论:肥胖患者血浆apoM显著降低,apoM水平与CRP、TNF-α、IL-6水平密切相关,apoM可能受到这些炎症因子的调控。
Objective: To observe the level of apolipoprotein M in obese patients and to explore its relationship with inflammatory factors. Methods: The body weight, body mass index, body mass index, fasting venous blood, lipopolysaccharide, apoM, IL-6, C Reactive protein (CRP), tumor necrosis factor alpha (TNF-alpha). Results: The levels of plasma apoM and HDL-C and the levels of IL-6, TNF-α and CRP in obese patients were significantly lower than those in obese patients (P <0.05) The plasma apoM was negatively correlated with the levels of IL-6, TNF-α and CRP. Conclusion: ApoM is significantly decreased in obese patients. The level of apoM is closely related to the levels of CRP, TNF-α and IL-6. ApoM may be regulated by these inflammatory factors.