本文报告4例口周角化棘皮瘤,除有广泛的神经周围侵犯外,3例还伴有静脉内侵犯。患者男、女各2例,年龄为27～80岁。3例皮损发生于上唇,1例发生在右颊近口唇处,大小约1～4cm。2例伴剧烈疼痛,2例有局部破坏。3例的肿瘤被切除后,很快又复发。再次切除后,随访24～44个月未复发。1例于切除后7个月,因其他原因死 This article reports 4 cases of keratoacanthoma on the oral periphery, in addition to extensive peripheral nerve invasion, 3 cases also accompanied by intravenous invasion. Patients were male and female in 2 cases, aged 27 to 80 years. 3 cases of skin lesions occurred in the upper lip, 1 case occurred in the right cheek near the lip, the size of about 1 ~ 4cm. Two patients had severe pain and two patients had local destruction. Three of the tumors were removed and soon recurred. After re-excision, there was no recurrence after 24-44 months of follow-up. 1 case died 7 months after resection due to other reasons