论文部分内容阅读
目的:探讨中国北方汉族人群中,老年缺血性卒中后继发性癫痫与核因子E2相关因子2(Nrf2)基因多态性的关系。方法:选择2013-01-2016-06在本科治疗的53例老年缺血性卒中后继发性癫痫患者作为癫痫组,在同期于我科治疗的老年缺血性卒中未合并癫痫的患者中随机选择100例作为卒中组,同时随机选择同期在我院体检的老年健康体检者100例作为对照组,采用SNaPshot法比较Nrf2基因型多态性在各组间的差异。结果:癫痫组与卒中组、对照组比较,Nrf2基因rs35652124位点(AG+GG)基因型和G等位基因频率均显著高于后2组(均P<0.05)。卒中组与对照组比较,2组患者基因型和等位基因频率比较差异均无统计学意义。多因素Logistic回归分析结果显示Nrf2基因rs35652124位点A>G是缺血性卒中患者继发癫痫的危险因素(OR=1.230,95%CI:1.008~1.871,P=0.041)。结论:对于缺血性卒中患者,Nrf2基因rs35652124位点多态性与继发性癫痫密切相关。
Objective: To investigate the relationship between the secondary epilepsy and the nuclear factor E2-related factor 2 (Nrf2) gene polymorphism in elderly people with ischemic stroke in northern Chinese Han population. Methods: Selected 2013-01-2016-06 53 cases of secondary epilepsy after senile ischemic stroke as epilepsy group undergraduate, were randomly selected in the same period in patients with senile ischemic stroke without epilepsy treated in our department One hundred patients were selected as stroke group and 100 healthy elderly subjects were selected as control group randomly during the same period. SNaPshot method was used to compare the difference of Nrf2 genotypes in each group. Results: Compared with the stroke group and the control group, the frequencies of rs35652124 (AG + GG) genotype and G allele in epilepsy group were significantly higher than those in the latter two groups (all P <0.05). Compared with the control group, there was no significant difference in the genotype and allele frequencies between the two groups. Multivariate logistic regression analysis showed that the rs35652124 locus A> G of Nrf2 gene was a risk factor for secondary epilepsy in patients with ischemic stroke (OR = 1.230, 95% CI: 1.008-1.871, P = 0.041). Conclusion: The rs35652124 polymorphism of Nrf2 gene is closely related to secondary epilepsy in patients with ischemic stroke.