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二色桌片参〔Mensamaria intercedens( L ampert)〕的体壁经水煮提、分离、最后经 Sephadex G- 2 0 0柱层析纯化得二色桌片参糖蛋白 ( GPMI- )。GPMI- 经酶解后得二色桌片参糖蛋白 ( GPMI- )。分别研究了GPMI- 和 GPMI- 的性状、化学组成和抗肿瘤活性 ,结果表明 :GPMI- 和 GPMI- 都是糖蛋白 ,但蛋白组成和糖含量明显不同。GPMI- 对小鼠 S180 肉瘤有明显抑制作用 ,而无直接毒性 ,抑瘤率为 4 8.8%。而 GPMI- 却能显著提高 S180 肉瘤荷瘤小鼠的脾指数 ,呈免疫增强作用。
The body wall of the Mansamaria intercedens (L ampert) was boiled, separated and finally purified by column chromatography on a Sephadex G-200 to obtain the two-color tabletop ginseng glycoprotein (GPMI-). GPMI-Digested Table Glucose Protein (GPMI-) after enzymolysis. The traits, chemical composition and antitumor activity of GPMI- and GPMI- were studied. The results showed that both GPMI- and GPMI- were glycoproteins, but the protein composition and sugar content were significantly different. GPMI- has a significant inhibitory effect on mouse S180 sarcoma without direct toxicity, with a tumor inhibition rate of 48.8%. However, GPMI- can significantly increase the spleen index of S180-bearing sarcoma-bearing mice, showing an immunopotentiating effect.