先天性马蹄内翻足(congenital clubfoot,CCF)是一种常见的严重影响足的形态与功能的先天性畸形,占足部畸形的85%,发病率全世界约为1‰,男女比例约为2～2.5:1。中国人患病率为0.39‰,夏威夷人和毛利人为7‰,高加索人约为1.2‰,波利尼西亚人约为6.8‰,不同种族患病率不同。CCF患者同胞患病几率增加约30倍。两位同胞同时患病在单卵双生中的几率高达32.5%,而在双卵双生中仅为 Congenital clubfoot (congenital clubfoot, CCF) is a common form of congenital malformations that seriously affect the morphology and function of foot, accounting for 85% of the foot deformities, the incidence of the world is about 1 ‰, the ratio of male to female is about 2 ~ 2.5: 1. The prevalence rate of Chinese is 0.39 ‰, Hawaiian and Maori 7 ‰, Caucasians 1.2 ‰, Polynesians 6.8 ‰, different racial prevalence rates. CCF patients with siblings increased risk of about 30 times. The odds of the two siblings getting sick at the same time in monozygotic twins are as high as 32.5%