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少支胶质细胞肿瘤最重要的分子遗传学特征是1p/19q等位基因的杂合性缺失,近年来已初步证实了其基因表型变化与生物学行为之间的联系,即分子遗传学特征与其发生发展、放化疗敏感性、治疗方式选择以及预后之间存在着相关性,大大促进了以形态学为基础的诊疗模式向以分子发生机制为基础的新的诊疗模式的转变。
The most important molecular genetic feature of oligo-glia is the loss of heterozygosity of the 1p / 19q allele. In recent years, the relationship between the phenotypic changes and the biological behavior has been initially confirmed, ie, molecular genetics The correlation between features and their development, chemosensitivity to chemoradiotherapy, choice of treatment modalities and prognosis has greatly facilitated the transition from morphological diagnosis and treatment model to new diagnosis and treatment model based on molecular mechanism.