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在西方国家,儿童炎症性肠病(IBD)发病率呈进行性上升态势。然而迄今为止尚无一项简单而可靠用于评估该病活动度、预测复发的非侵袭性方法,该病的诊断与分期仍依据临床、内窥镜检查、组织学分析以及放射学标准综合判断。本研究的目的旨在确定测定直肠一氧化氮(NO)产物能否反映IBD儿童的肠道局部炎症变化和疾病活动度。 方法 研究对象为40例儿童,根据内窥镜检查和粘膜活检确立诊断、疾病活动度、局部受累情况,其中溃疡性结肠炎(UC)20例,克罗恩
In Western countries, the incidence of childhood inflammatory bowel disease (IBD) is progressively increasing. However, there is no simple and reliable non-invasive method for assessing the activity of the disease and predicting relapse so far. The diagnosis and staging of the disease are still based on clinical, endoscopic, histological and radiological criteria . The purpose of this study was to determine whether the determination of rectal nitric oxide (NO) production reflects the changes in intestinal gut inflammation and disease activity in IBD children. Methods Forty children were enrolled in the study. According to endoscopy and mucosal biopsy, diagnosis, disease activity and local involvement were established. Among them, 20 were ulcerative colitis (UC), Crohn’s disease