甲型肝炎病毒(HAV)排出的早期研究表明,在病人黄疸发作前28～35天的粪便无感染性,发作前14～21天的粪便可引起肝炎。近年来用免疫电镜研究证明,在黄疸发作前5～11天粪便中即出现甲型肝炎病毒。然而,在排毒期间不是都能找到病毒的。在Krugman等早期研究指出,在黄疸发作后10天内的粪便是有传染性的,但在黄疸发作后19天则无传染性。有些报道认为在黄疸已出现或血清转氨酶达高峰时,病人粪便中即查不到HAV,但也有与此相反的。本文作 Earlier studies of Hepatitis A virus (HAV) excretion showed that faeces were non-infectious 28 to 35 days prior to the onset of jaundice and that stools 14 to 21 days before the onset of hepatitis caused hepatitis. In recent years, immunoelectron microscopy studies have shown that 5 to 11 days before the onset of jaundice in the faeces, ie, hepatitis A virus. However, not all viruses are found during detoxification. Earlier studies by Krugman et al. Indicated that faeces were infectious within 10 days after the onset of jaundice, but not contagious 19 days after the onset of jaundice. Some reports suggest that HAV can not be detected in the stool of a patient when jaundice has taken place or the serum aminotransferase has reached a peak, but this is the opposite. This article as