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不同鼠龄大鼠173只用于观察发育过程中小肠乳糖酶活性的变化,同时测定蔗糖酶及碱性磷酸酶活性。另用60只小鼠研究乳糖、氢化可的松及胰岛素对酶活性发育的影响。结果表明:出生前胎鼠小肠中乳糖酶活性已开始增加,出生后前三周空、回肠酶活性均处于很高水平,以后二者迅速下降至成年低水平。相反,蔗糖酶及碱性磷酸酶在成年期均具有高活性。发育过程中给动物胃饲乳糖、注射氢化可的松或胰岛素均使小肠乳糖酶活性下降速度变慢,但不能阻止其下降。这些说明哺乳动物大鼠的成年期小肠乳糖酶缺乏是该酶正常发育成熟的发现
173 rats of different age were used to observe the change of lactase activity in the process of development, and the activities of sucrase and alkaline phosphatase were measured. Another 60 mice were studied lactose, hydrocortisone and insulin on the development of enzyme activity. The results showed that the activity of lactase in the small intestine of the fetus began to increase before birth and the activity of ileum in the first three weeks after birth was very high and both of them rapidly decreased to the adult low level afterwards. In contrast, invertase and alkaline phosphatase are both highly active in adulthood. During the development of animals fed lactose lactose, injection of hydrocortisone or insulin slow down the activity of small intestine lactase, but can not prevent its decline. These findings suggest that the absence of lactase in the intestine of mammalian rats is a result of the normal maturation of the enzyme