纯红细胞再生障碍(PRCA)是一种以红细胞压积减低。网织红细胞减少和骨髓红系增生不良为特征的疾病。由于抗体直接作用于红系祖细胞或红细胞生成素,或 T 细胞介导抑制红细胞生成所致。免疫功能障碍被怀疑为慢性PRCA 的原因。红系祖细胞缺陷也被认为是PRCA 的病因。治疗用肾上腺皮质类固醇,细胞毒药物主要有环磷酰胺、硫唑嘌呤、长春新碱和6巯基嘌呤。其他治疗方法包括胸腺切除、同化 Pure red cell aplasia (PRCA) is a hematocrit reduction. Reticulocyte reduction and myeloid erythroid hyperplasia characterized by disease. Since antibodies act directly on erythroid progenitor cells or erythropoietin, or on T cell-mediated suppression of erythropoiesis. Immune dysfunction is suspected of being a cause of chronic PRCA. Depletion of erythroid progenitor cells is also considered the cause of PRCA. Treatment with adrenal corticosteroids, cytotoxic drugs are cyclophosphamide, azathioprine, vincristine and 6 mercaptopurine. Other treatments include thymectomy and assimilation