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目的探讨滤过手术对角膜内皮细胞的影响及其原因。方法检查64只接受小梁切除的原发性青光眼，手术前、后的角膜内皮细胞数量及术后前房深度的变化和炎症反应情况。结果术后64只眼角膜内皮细胞数均比术前减少，差异有显著性（t＝2．508，P＜0．05）；术后前房越浅，内皮细胞损失率越大，相关分析表明，两者间存在着一定的相关关系，（r＝0．7587，t＝9．170，P＜0．01）；炎症反应重的眼比炎症反应轻的眼内皮细胞损失率高。结论提高手术质量，减少术后浅前房和炎症反应的发生或缩短其存在的时间，可降低术后内皮细胞的损失率。
Objective To investigate the effect of filtration surgery on corneal endothelial cells and its causes. Methods Sixty-four primary glaucoma patients undergoing trabeculectomy, the number of corneal endothelial cells before and after surgery, the depth of anterior chamber and the inflammatory response were examined. Results The number of corneal endothelial cells in 64 eyes decreased after operation, the difference was significant (t = 2.508, P <0.05). The lighter the anterior chamber, the greater the loss rate of endothelial cells. Correlation analysis The results showed that there was a certain correlation between the two (r = 0.7587, t = 9.170, P <0.01). Conclusion Increasing the quality of surgery, reducing the occurrence of postoperative shallow anterior chamber and inflammatory reaction or shortening the time of its existence can reduce the rate of postoperative loss of endothelial cells.