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目的探讨大肠癌患者血浆D-二聚体的变化与疗效的关系。方法检测60例进展期大肠癌患者术前及术后2年的血浆D-二聚体浓度。结果术前进展期大肠癌缓解组血浆D-二聚体低于转移组(P<0.01),治疗后缓解组血浆D-二聚体低于术前(P<0.01),转移组血浆D-二聚体高于术前(P<0.01)。结论进展期大肠癌患者血液处于高凝状态。恶性程度高、侵袭性强、对手术化疗反应差的肿瘤患者在治疗前后均有较高的D-二聚体水平。
Objective To investigate the relationship between the changes of plasma D-dimer and the curative effect in patients with colorectal cancer. Methods Sixty patients with advanced colorectal cancer were tested for plasma D-dimer concentration before and 2 years after operation. Results The plasma D-dimer in patients with advanced colorectal cancer was lower than that in patients with metastasis (P <0.01), and the plasma D-dimer in remission group was lower than that before operation (P <0.01) Dimer was higher than preoperative (P <0.01). Conclusion The blood of patients with advanced colorectal cancer is hypercoagulable. Malignant, highly aggressive, poor response to surgical chemotherapy in patients with cancer before and after treatment have a higher level of D-dimer.