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目的探讨米非司酮配伍米索前列醇终止妊娠天数为35～90d者阴道出血的相关因素。方法采用SPSS18.0统计学软件,单因素分析采用χ2检验,多因素分析采用多因素非条件logistic回归分析。对该中心2009年12月—2013年1月自愿要求药物流产对象的阴道出血量与可能的影响因素进行描述和分析。结果该研究共961例对象实施了药物流产,出血量多者占43.2%。单因素分析结果显示:年龄为35～40岁者出血量多于17～34岁者;孕期为50～90d者多于35～49d者;有妊娠史和有分娩史者分别高于无妊娠史和无分娩史者;多因素非条件logistic回归分析结果表明:孕期为50～90d(OR=1.824,可信区间为1.294～2.571)、有妊娠史(OR=1.994,可信区间为1.408～2.825)和有分娩史(OR=1.335,可信区间为1.977～1.823)3个因素是出血量多的危险因素。结论米非司酮配伍米索前列醇终止早孕的阴道出血量与年龄、孕期、妊娠史、分娩史有关,且孕期为50～90d、有妊娠史和有分娩史为出血量多的危险因素。
Objective To investigate the related factors of vaginal bleeding with mifepristone and misoprostol for the termination of pregnancy for 35-90 days. Methods SPSS18.0 statistical software, single factor analysis using χ2 test, multivariate analysis using multivariate non-conditional logistic regression analysis. Describes and analyzes the amount of vaginal bleeding voluntarily requested by the center from December 2009 to January 2013 and the possible influencing factors. Results A total of 961 subjects underwent medical abortion in this study, with 43.2% of them having the largest amount of bleeding. Univariate analysis showed that: the age of 35 to 40 years of bleeding more than 17 to 34 years of age; pregnancy 50 to 90d were more than 35 to 49d; pregnancy history and delivery history were higher than those without pregnancy history (OR = 1.824, confidence interval was 1.294 ~ 2.571), with a history of pregnancy (OR = 1.994, confidence interval of 1.408 ~ 2.825 ) And history of childbirth (OR = 1.335, confidence interval of 1.977 ~ 1.823) were the risk factors for more bleeding. Conclusions Mifepristone combined with misoprostol to prevent vaginal bleeding in early pregnancy is related to age, gestational age, pregnancy history and delivery history. Pregnancy is between 50 and 90 days. Pregnancy history and delivery history are risk factors for bleeding volume.