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目的:研究苦豆草中槐定碱在大鼠血浆中的浓度及药动学。方法:给大鼠灌胃苦豆草水溶液,用HPLC法测定血浆中槐定碱的浓度,估算相应的药动学参数。结果:在本实验所建立的方法中,槐定碱的回收率达到89.09%,准确度高于94.90%;大鼠灌胃苦豆草水溶液含40 mg/kg槐定碱后的t1/2(α)、t1/2(β),Tmax、Cmax、CL/F、AUC0~t分别为(0.28±1.70)h、(3.66±1.23)h、(0.75±8.66)h、(1.62±0.13)mg/L、(0.10±0.02)L/(h.kg)、(4.84±0.20)mg/(μL.h),其在大鼠体内的分布符合二室模型。结论:本实验所建立的方法适合大批量的血样分析,该方法能够满足药动学研究的需要。
Objective: To study the concentration and pharmacokinetics of sophoridine in plasma of rats. Methods: The rats were orally administered with aqueous solution of Sophora flavescens, and the sophoridine concentration was determined by HPLC. The corresponding pharmacokinetic parameters were estimated. Results: The recovery rate of sophoridine was 89.09% and the accuracy was higher than 94.90% in the method established in this experiment. After the rats were orally administered with 40 mg / kg sophoridine, the ratio of t1 / 2 (0.28 ± 1.70) h, (3.66 ± 1.23) h, (0.75 ± 8.66) h, (1.62 ± 0.13) mg /L,(0.10 ± 0.02) L / (h.kg), (4.84 ± 0.20) mg / (μL.h), and its distribution in the rat is consistent with a two-compartment model. Conclusion: The method established in this experiment is suitable for large-scale blood sample analysis, which can meet the needs of pharmacokinetic studies.