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目的从天津地区胃癌发病的危险因素方面探讨胃癌的发病机制,旨在为胃癌的病因学研究和防治工作提供线索和依据。方法对天津地区100例胃镜检查或手术后,经病理检查确诊为胃癌患者为病例组,并以同期胃镜诊断为慢性浅表性胃炎和慢性萎缩性胃炎患者109例作为对照组,均通过统一制表进行相关因素的问卷调查,专人登记。对调查结果进行了Logistic回归分析,以确定饮食、情绪、生活习惯等危险因素与胃癌发生的关系。结果嗜酒和有恶性肿瘤家族史均会很大程度上增加患胃癌的危险性,嗜酒(酒精量>40 g/d)患胃癌的OR值是2.448(95%CI:1.157～5.182),直系亲属患恶性肿瘤发生胃癌的OR值是3.469(95%CI:1.392～8.644)。结论嗜酒和有恶性肿瘤家族史均会很大程度上增加患胃癌的危险程度。
Objective To investigate the pathogenesis of gastric cancer from the risk factors of gastric cancer in Tianjin and to provide clues and evidences for the etiological research and prevention and treatment of gastric cancer. Methods A total of 109 patients with chronic superficial gastritis and chronic atrophic gastritis who were diagnosed as gastric cancer by pathology were enrolled in the study. Table related to the questionnaire survey, personal registration. Logistic regression analysis of the survey results to determine the relationship between diet, mood, lifestyle and other risk factors and the occurrence of gastric cancer. Results Both alcohol abuse and family history of malignancy increased the risk of gastric cancer to a large extent. The odds ratio for alcohol consumption (alcohol> 40 g / d) was 2.448 (95% CI: 1.157-5.182) The odds ratio for gastric cancer in immediate family members with malignant tumors was 3.469 (95% CI: 1.392-8.644). Conclusion Both alcoholism and a family history of malignancies greatly increase the risk of developing gastric cancer.