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目的探究扶正固本汤联合化疗对宫颈癌患者免疫功能的影响。方法选取60例宫颈癌患者,随机分为观察组和对照组各30例。对照组采用顺铂和氟尿嘧啶治疗,观察组在此基础上给予扶正固本汤治疗,比较治疗前后患者免疫细胞(CD3+、CD4+、CD8+、CD4+/CD8+和NK)、免疫因子(IFN-γ、IL-2、IL-4、IL-6和IL-10)、肝功能(ALT和AST)和肾功能(BUN和Cr)水平。结果与治疗前比较,2组免疫细胞(CD3+、CD4+、CD4+/CD8+和NK)和免疫因子(IFN-γ、IL-2)均升高,差异有统计学意义(P<0.05);CD8+、炎症因子(IL-4、IL-6和IL-10)、肝功能(ALT和AST)、肾功能(BUN和Cr)均降低,差异有统计学意义(P<0.05);治疗后,观察组各项指标变化均较对照组明显,差异有统计学意义(P<0.05)。结论扶正固本汤联合化疗能够有效的改善宫颈癌患者免疫因子和免疫细胞水平,对宫颈癌患者的康复具有重要的临床意义。
Objective To investigate the effect of Fuzheng Guben decoction combined with chemotherapy on the immune function of cervical cancer patients. Methods Sixty patients with cervical cancer were selected and randomly divided into observation group and control group with 30 cases each. The control group was treated with cisplatin and fluorouracil. The observation group was given Fuzheng Guben decoction on the basis of the above treatment. The immune cells (such as CD3 +, CD4 +, CD8 +, CD4 + / CD8 + and NK), immune factors (IFN- γ, IL -2, IL-4, IL-6 and IL-10), liver function (ALT and AST) and renal function (BUN and Cr) Results Compared with those before treatment, the numbers of immune cells (CD3 +, CD4 +, CD4 + / CD8 + and NK) and the immune factors (IFN-γ and IL-2) in the two groups were significantly increased Inflammatory factors (IL-4, IL-6 and IL-10), liver function (ALT and AST) and renal function (BUN and Cr) were significantly lower than those in control group (P <0.05) The changes of each index were significantly higher than that of the control group, the difference was statistically significant (P <0.05). Conclusion Fuzheng Guben decoction combined with chemotherapy can effectively improve the immune factors and immune cells in patients with cervical cancer, and has important clinical significance for the rehabilitation of patients with cervical cancer.